EJPAU 2006. Boratyński Z. , Pedrycz A. P-53 PROTEIN AND PROTEINS FROM BCL-2 FAMILY IN THE HEART OF RAT AFTER ADRIAMYCIN ADMINISTRATION. IMMUNOHISTOCHEMICAL EVALUATION

Electronic Journal of Polish Agricultural Universities (EJPAU) founded by all Polish Agriculture Universities presents original papers and review articles relevant to all aspects of agricultural sciences. It is target for persons working both in science and industry,regulatory agencies or teaching in agricultural sector. Covered by IFIS Publishing (Food Science and Technology Abstracts), ELSEVIER Science - Food Science and Technology Program, CAS USA (Chemical Abstracts), CABI Publishing UK and ALPSP (Association of Learned and Professional Society Publisher - full membership). Presented in the Master List of Thomson ISI.

2006
Volume 9
Issue 2

Topic:

Veterinary Medicine

ELECTRONIC
JOURNAL OF
POLISH
AGRICULTURAL
UNIVERSITIES

Boratyński Z. , Pedrycz A. 2006. P-53 PROTEIN AND PROTEINS FROM BCL-2 FAMILY IN THE HEART OF RAT AFTER ADRIAMYCIN ADMINISTRATION. IMMUNOHISTOCHEMICAL EVALUATION, EJPAU 9(2), #11.
Available Online: http://www.ejpau.media.pl/volume9/issue2/abs-11.html

P-53 PROTEIN AND PROTEINS FROM BCL-2 FAMILY IN THE HEART OF RAT AFTER ADRIAMYCIN ADMINISTRATION. IMMUNOHISTOCHEMICAL EVALUATION

Zbigniew Boratyński¹, Agnieszka Pedrycz²
¹ Deaprtment of Animal Anatomy and Histology, Agricultural University of Lublin, Poland
² Department of Histology and Embryology, with Lab of Experimental Cytology, Medical University of Lublin, Poland

ABSTRACT

Adriamycin (ADR) – the antineoplastic antibiotics has confirmed proapoptotic activity, mainly on neoplastic cells and young quick dividing cells. Cardiotoxicity of Adriamycin is limitating in antineoplastic therapy. The purpose of study was an evaluation of internal pathway of induction of signal to the apoptosis in myocardial cells of rat, which had administered Adriamycin. The sign of late cardiotoxicity after Adriamycin is coagulative necrosis. In present study was noticed also increased apoptosis of cells in rat heart, which was induced via mitochondrial pathway, with activation of p-53 protein and with BAX/Bcl-2 ratio > 1 – with prevalence of proapoptotic BAX protein.

Key words: apoptosis, heart, adriamycin, Bcl-2, BAX, P-53, immunohistochemistry.

Zbigniew Boratyński
Deaprtment of Animal Anatomy and Histology,
Agricultural University of Lublin, Poland
Akademicka 12, 20-934 Lublin, Poland
phone: (+48 81) 445-60-33, 445-60-62
email: zbyszek.boratynski@ar.lublin.pl

Agnieszka Pedrycz
Department of Histology and Embryology,
with Lab of Experimental Cytology,
Medical University of Lublin, Poland
Al. Racławickie 1, 20-059 Lublin, Poland

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