Electronic Journal of Polish Agricultural Universities (EJPAU) founded by all Polish Agriculture Universities presents original papers and review articles relevant to all aspects of agricultural sciences. It is target for persons working both in science and industry,regulatory agencies or teaching in agricultural sector. Covered by IFIS Publishing (Food Science and Technology Abstracts), ELSEVIER Science - Food Science and Technology Program, CAS USA (Chemical Abstracts), CABI Publishing UK and ALPSP (Association of Learned and Professional Society Publisher - full membership). Presented in the Master List of Thomson ISI.

Copyright © Wydawnictwo Akademii Rolniczej we Wroclawiu, ISSN 1505-0297

Pedrycz A. , Wieczorski M. , Boratyński Z. , Czerny K. , Flieger S. 2005. ULTRASTRUCTURAL EVALUATION OF RENAL CONVOLUTED TUBULES OF FEMALE RATS, WHICH HAD PREGNANCY COMPLICATED WITH SECONDARY PREECLAMPSIA, EJPAU 8(2), #02.
Available Online: http://www.ejpau.media.pl/volume8/issue2/abs-02.html

ABSTRACT

The purpose of present study was analysis of structure of convoluted tubules epithelial cells, which were coming from female rats, which had pregnancy complicated with preeclampsia after nephrotic syndrome induced by adriamycin. In experiment were used 16 female rats divided into two groups: experimental and control (each group contain 8 individuals). Rats from experimental group had administered intraperitoneally adriamycin in dose 5 mg/kg of body weight to induce nephrotic syndrome. Female rats were paired with males 4 weeks from drug administration, and decapitated 4 weeks after delivery. Systolic blood pressure was taken from animals on 10th, 20th day of pregnancy and 10 days and 4 weeks after delivery. In urine from 24 hour collection on 19^th day of pregnancy and 27 days after delivery protein concentration was determined. Histological sections from collected kidneys were observed in electron microscopy. Results show the significant damage in epithelial cells in convoluted tubules with features of the apoptosis. Presence of homogenous casts in tubular lumen was the evidence of excessive proteinuria. The histological changes were similar to that which appear in convoluted tubules rat females during pregnancy complicated with preeclampsia. However features of preeclampsia (hypertension, proteinuria, edemas) present during pregnancy disappeared or decreased starting from 10th day after delivery.

Key words: St post preeclampsia, tubules of kidneys, rat?s mothers, electron microscopy, adriamycin.

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Agnieszka Pedrycz
Department of Histology and Embryology,
with Lab of Experimental Cytology,
Medical University of Lublin, Poland
Al. Racławickie 1, 20-059 Lublin, Poland


Marcin Wieczorski
Department of Histology and Embryology,
with Lab of Experimental Cytology,
Medical University of Lublin, Poland
Al. Racławickie 1, 20-059 Lublin, Poland

Zbigniew Boratyński
Deaprtment of Animal Anatomy and Histology,
Agricultural University of Lublin, Poland
Akademicka 12, 20-934 Lublin, Poland
phone: (+48 81) 445-60-33, 445-60-62
email: zbyszek.boratynski@ar.lublin.pl

Krystyna Czerny
Department of Histology and Embriology,
with Lab of Experimental Cytology,
Medical University of Lublin, Poland
Radziwiłłowska 11, 20-080 Lublin, Poland


Stanisław Flieger
Deaprtment of Animal Anatomy and Histology,
Agricultural University of Lublin, Poland
Akademicka 12, 20-950 Lublin, Poland
phone: (+48 81) 445-65-84

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Responses to this article, comments are invited and should be submitted within three months of the publication of the article. If accepted for publication, they will be published in the chapter headed 'Discussions' and hyperlinked to the article.

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