DOI:10.30825/5.ejpau.188.2020.23.3, EJPAU 23(3), #01.
Available Online: http://www.ejpau.media.pl/volume23/issue3/abs-01.html
WHY SOME YARROWIA LIPOLYTICA STRAINS SECRET CITRIC ACID TO THE MEDIUM?
Department of Biotechnology and Food Microbiology, Wroc│aw University of Environmental and Life Sciences, Poland
Despite many studies, the “check points” of metabolic regulation of citric acid (CA) secretion by the yeasts Y.lipolytica still remain unknown. In this manuscript, some possible aspects of strain dependent secretion as well as CA metabolism regulation were discussed. Keys enzymes’ activities, substrate concentration, affinity of the uptake systems, intracellular CA concentration and strains abilities were the main points taken into consideration. The direction for the future studies emerged from this review, mainly connected to cellular and mitochondrial citrate transport systems and cellular substrates transporters (glucose, fructose, glycerol, ethanol and acetate), give promising starting point for future efficient strain development.
Key words: Yarrowia lipolytica, citrate synthase, intracellular CA, glucose consumption, RAPD.
Department of Biotechnology and Food Microbiology,
Wroc│aw University of Environmental and Life Sciences, Poland
Responses to this article, comments are invited and should be submitted within three months of the publication of the article. If accepted for publication, they will be published in the chapter headed 'Discussions' and hyperlinked to the article.