Electronic Journal of Polish Agricultural Universities (EJPAU) founded by all Polish Agriculture Universities presents original papers and review articles relevant to all aspects of agricultural sciences. It is target for persons working both in science and industry,regulatory agencies or teaching in agricultural sector. Covered by IFIS Publishing (Food Science and Technology Abstracts), ELSEVIER Science - Food Science and Technology Program, CAS USA (Chemical Abstracts), CABI Publishing UK and ALPSP (Association of Learned and Professional Society Publisher - full membership). Presented in the Master List of Thomson ISI.

Copyright © Wydawnictwo Akademii Rolniczej we Wroclawiu, ISSN 1505-0297

Muszyński S. , Tomczyk A. , Dobrowolski P. , Tomaszewska E. , Hułas-Stasiak M. 2016. PRELIMINARY STUDY OF TIME-DEPENDENT INFLUENCE OF MATERNAL NUTRITION WITH ADDITION OF β-HYDROXY- β -METHYLBUTYRATE ON THE BODY WEIGHT AND SELECTED ORGANS WEIGHT IN THE NEW-BORN SPINY MICE (ACOMYS CAHIRINUS) OFFSPRING, EJPAU 19(4), #08.
Available Online: http://www.ejpau.media.pl/volume19/issue4/abs-08.html

ABSTRACT

Interferences into maternal nutrient are used in studies related to prenatal programming – the permanent changes in homeostasis of regulatory physiological mechanisms. In present study, the effect of HMB (β-hydroxy-β-methylbutyrate) maternal administration on body composition in newborn offspring of spiny mouse (Acomys cahirinus) was studied. The spiny mice were randomized into control (fed with a standard diet) and two experimental sub-groups additionally supplemented with HMB – 0.2 mg/kg of body weight per day in accordance with the time of HMB administration during gestation: period I lasting from the 13^th to the 26^th day of the gestation and period II lasting from day 26 to day 39 of gestation (lasting generally 39–40 days). Newborn spiny mice from the control group, the HMB I and HMB II groups were weighted and euthanized, and their organ weights were recorded. Maternal HMB-treatment did not significantly influence the body weight of newborns, although the offspring delivered by dams administered with HMB during middle gestation were significantly smaller compared to newborns delivered by dams treated with HMB during the last period of gestation. Lung and spleen weights were increased in the offspring delivered by HMB-treated dams irrespective of the period of administration. The weights of liver, kidneys and heart in the offspring delivered by HMB-treated dams in middle gestation were increased compared to the control group.

   This study showed a time-dependent maternal influence of HMB supplementation on the development of kidneys and liver. The increase in the weight of basal vital organs of newborn offspring in spiny mouse was not proportional to their body size.

Key words: prenatal programing, β-hydroxy β-methylbutyrate, spiny mouse, offspring development.

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Siemowit Muszyński
Department of Physics, Faculty of Production Engineering, University of Life Sciences in Lublin, Poland


Agnieszka Tomczyk
Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Lublin, Poland


Piotr Dobrowolski
Department of Comparative Anatomy and Anthropology, Maria Curie-Skłodowska University, Lublin, Poland


Ewa Tomaszewska
Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Lublin, Poland
E-mail: ewaRST@interia.pl
Phone +48 4456973
Fax +48 4456973
email: ewa.tomaszewska@up.lublin.pl

Monika Hułas-Stasiak
Department of Comparative Anatomy and Anthropology, Maria Curie-Skłodowska University, Lublin, Poland

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Responses to this article, comments are invited and should be submitted within three months of the publication of the article. If accepted for publication, they will be published in the chapter headed 'Discussions' and hyperlinked to the article.

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