EJPAU 2012. Szwajgier D. , Borowiec K. SCREENING FOR CHOLINESTERASE INHIBITORS IN SELECTED FRUITS AND VEGETABLES

Electronic Journal of Polish Agricultural Universities (EJPAU) founded by all Polish Agriculture Universities presents original papers and review articles relevant to all aspects of agricultural sciences. It is target for persons working both in science and industry,regulatory agencies or teaching in agricultural sector. Covered by IFIS Publishing (Food Science and Technology Abstracts), ELSEVIER Science - Food Science and Technology Program, CAS USA (Chemical Abstracts), CABI Publishing UK and ALPSP (Association of Learned and Professional Society Publisher - full membership). Presented in the Master List of Thomson ISI.

2012
Volume 15
Issue 2

Topic:

Biotechnology

ELECTRONIC
JOURNAL OF
POLISH
AGRICULTURAL
UNIVERSITIES

Szwajgier D. , Borowiec K. 2012. SCREENING FOR CHOLINESTERASE INHIBITORS IN SELECTED FRUITS AND VEGETABLES, EJPAU 15(2), #06.
Available Online: http://www.ejpau.media.pl/volume15/issue2/abs-06.html

SCREENING FOR CHOLINESTERASE INHIBITORS IN SELECTED FRUITS AND VEGETABLES

Dominik Szwajgier, Kamila Borowiec
Department of Food Technology and Storage, Lublin Agricultural Academy, Poland

ABSTRACT

Plants deliver a great number of compounds among which some of them can exert a beneficial therapeutic role in the treatment of Alzheimer's disease (e.g. huperzine A, galanthamine, physostigmine). In the present study it was shown that 17 edible fruits or vegetables effectively inhibited AChE and/or BChE. The highest anti-ChE activity was demonstrated in the case of the juice produced from peach (Prunus persica L.), water extracts prepared from dill leaves, wild strawberry fruit, potato tubers and juices produced using apples var. Idared and Champion. Extracts from parsley (leaves) and celery exhibited significantly higher activity towards AChE than BChE. AChE activity was not diminished by extracts prepared from strawberry, bean, broccoli, parsley (root) and tomato. These results confirm that selected fruits and vegetables can be an interesting source of ChE inhibitors with the possible potential in the context of the restoring of cognitive function and improving the memory. Therefore, there is a possibility to compose the diet containing fruits and vegetables aiming the protection against memory deficits caused by AD.

Key words: acetylcholinesterase, butyrylcholinesterase, inhibitor, Alzheimer’s disease.

Dominik Szwajgier
Department of Food Technology and Storage,
Lublin Agricultural Academy, Poland
Skromna 8, 20-704 Lublin, Box 158, Poland
ph. (48 81) 444 63 10
fax (48 81) 444 63 11
email: dszwajgier@hotmail.com

Kamila Borowiec
Department of Food Technology and Storage,
Lublin Agricultural Academy, Poland

Responses to this article, comments are invited and should be submitted within three months of the publication of the article. If accepted for publication, they will be published in the chapter headed 'Discussions' and hyperlinked to the article.