Electronic Journal of Polish Agricultural Universities (EJPAU) founded by all Polish Agriculture Universities presents original papers and review articles relevant to all aspects of agricultural sciences. It is target for persons working both in science and industry,regulatory agencies or teaching in agricultural sector. Covered by IFIS Publishing (Food Science and Technology Abstracts), ELSEVIER Science - Food Science and Technology Program, CAS USA (Chemical Abstracts), CABI Publishing UK and ALPSP (Association of Learned and Professional Society Publisher - full membership). Presented in the Master List of Thomson ISI.
2010
Volume 13
Issue 3
Topic:
Veterinary Medicine
ELECTRONIC
JOURNAL OF
POLISH
AGRICULTURAL
UNIVERSITIES
Wojciechowski M. , Wałkuska G. 2010. GENE 53P AND ITS ROLE IN TUMOR DISEASE, EJPAU 13(3), #14.
Available Online: http://www.ejpau.media.pl/volume13/issue3/abs-14.html

GENE 53P AND ITS ROLE IN TUMOR DISEASE

Monika Wojciechowski, Grażyna Wałkuska
Subdepartment of Toxicology and Environmental Protection, Department of Pre-clinical Veterinary Scence, University of Life Sciences, Lublin, Poland

 

ABSTRACT


The p53 gene was the first tumour-suppressor gene to be identified. In normall cells p53 activity is very low. Activation occurs in response to cellular stresses and results in an increase in the levels of p53. This leads to either cell cycle arrest, which may allow time for DNA repair or cell death by apoptosis. P53 gene is transcriptional factor, which can activate transcription of adjacent genes. P53 remains the most commonly mutated gene in many human cancers, also in dogs it plays important role in cancerogenesis. P53 expression can be important prognostic factor in cancer desease. P53 mutations can be associated with poor prognosis, short overall survival and resistant for chemotherapy. Although wild type p53 role in response to chemotherapy is controversial, because it can also arrest tumor cells in cell cycle, protecting them from further cytotoxic damages induced by cytostatic drugs. In addition, mutant p53 can function as an onkogen, actively promote tumor formation.

Key words: p53 gene, tumor disease, chemotherapy.


Monika Wojciechowski
Subdepartment of Toxicology and Environmental Protection,
Department of Pre-clinical Veterinary Scence,
University of Life Sciences, Lublin, Poland
Akademicka 12, 20-033 Lublin, Poland
email: monika.wojciechowski@up.lublin.pl

Grażyna Wałkuska
Subdepartment of Toxicology and Environmental Protection,
Department of Pre-clinical Veterinary Scence,
University of Life Sciences, Lublin, Poland
Akademicka 12, 20-033 Lublin, Poland

Responses to this article, comments are invited and should be submitted within three months of the publication of the article. If accepted for publication, they will be published in the chapter headed 'Discussions' and hyperlinked to the article.