EJPAU 2002. Siwicki A. , Klein P. , Kazuń K. , Morand M. , Głąbski E. , Trapkowska S. INFLUENCE OF DIMERIZED LYSOZYME (KLP-602) ON THE IMMUNE RESPONSES INDUCED BY FUROGEN VACCINE IN RAINBOW TROUT (<I>ONCORHYNCHUS MYKISS</I>)

Electronic Journal of Polish Agricultural Universities (EJPAU) founded by all Polish Agriculture Universities presents original papers and review articles relevant to all aspects of agricultural sciences. It is target for persons working both in science and industry,regulatory agencies or teaching in agricultural sector. Covered by IFIS Publishing (Food Science and Technology Abstracts), ELSEVIER Science - Food Science and Technology Program, CAS USA (Chemical Abstracts), CABI Publishing UK and ALPSP (Association of Learned and Professional Society Publisher - full membership). Presented in the Master List of Thomson ISI.

2002
Volume 5
Issue 2

Topic:

Veterinary Medicine

ELECTRONIC
JOURNAL OF
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AGRICULTURAL
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Siwicki A. , Klein P. , Kazuń K. , Morand M. , Głąbski E. , Trapkowska S. 2002. INFLUENCE OF DIMERIZED LYSOZYME (KLP-602) ON THE IMMUNE RESPONSES INDUCED BY FUROGEN VACCINE IN RAINBOW TROUT (ONCORHYNCHUS MYKISS), EJPAU 5(2), #01.
Available Online: http://www.ejpau.media.pl/volume5/issue2/veterinary/abs-01.html

INFLUENCE OF DIMERIZED LYSOZYME (KLP-602) ON THE IMMUNE RESPONSES INDUCED BY FUROGEN VACCINE IN RAINBOW TROUT (ONCORHYNCHUS MYKISS)

Andrzej K. Siwicki, Peter Klein, Krzysztof Kazuń, Marc Morand, Edward Głąbski, Sylwia Trapkowska

ABSTRACT

In the present study the possible stimulation of nonspecific and specific immune response after immunization induced by immersion Furogen (Aqua Health Ltd) vaccine were analysed in rainbow trout (Oncorhynchus mykiss). The modulation was attempted using a natural immunostimulant, dimerized lysozyme (KLP-602). Five groups of rainbow trout were given intraperitoneal injections of KLP-602 two days before vaccine, with vaccine, and two days after vaccine applicated by immersion. The results of cellular study showed that KLP-602 applicated before or with Furogen vaccine statistically significant (P<0.05) increased the total immunoglobulin secreting cells (ISC) and specific antibody secreting cells (ASC) levels, compared to the KLP-free (only vaccinated) group of fish. Analysis of the results shows no significant differences between group of fish where KLP-602 was applicated after vaccination and KLP-free (only vaccinated) group of fish. Analysis the results of humoral study shows that KLP-602 applicated

Key words: Lysozyme dimer, fish, Furogen vaccine, ASC, specific immune response.